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/set net_throttle off

XChat doing periodic /who's can be disabled with Preferences → User list, and unchecking the Track the away status option.

/set gui_tweaks 192
/set net_reconnect_delay 300
/set gui_input_spell off
/set gui_lagometer 2
/set gui_throttlemeter 2

http://t0x.in/xchatsetvars.html